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Efflux transporters use energy from ATP hydrolysis to pump potentially toxic lipophilic compounds back into the blood and limit the access of many therapeutically used drugs to the brain, providing a mechanism for brain capillary ECs to act as a chemical barrier (5759)

A protocol planned interim analysis was conducted for this cross-over study when 12 participants completed the first administration period (period 1), in order to re-assess the sample size based on the primary outcome data

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The interplay between gut dysbiosis, systemic inflammation, and neuroinflammation highlights the complexity of the mechanisms by which chronic ethanol consumption can contribute to depressive disorders